Ketamine as a Novel Antidepressant: From Synapse to Behavior

Updated: Oct 22, 2020

Introduction Recent reports of a rapid antidepressant effect of the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine, even in treatment-resistant populations, has spurred translational therapeutic and neuroscience research aimed at elucidating ketamine’s mechanism of action. This article provides a concise overview of research findings that pertain to the effects of low-dose ketamine at the cellular, neurocircuitry and behavioral levels and describes an integrated model of the action of ketamine in depression.

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